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  • Belladonna Sulfamethoxazole
Detailed description

Belladonna Sulfamethoxazole and Trimerhoprim Tablets Product Description Summary
Please use under the guidance of doctors
[drug name]
Generic name: Belladonna Sulfamethoxazole and Trimerhoprim Tablets
English Name: Sulfamethoxazole and Trimerhoprim Tablets Belladonna
Chinese Pinyin: Huangbianding Pian Dianqie
[character] this product is a kind of white film.
[indications] for Shigella caused by chronic bacillary dysentery and other sensitive pathogens cause enteritis.
[Specification] 0.4g sulfamethoxazole, trimethoprim 80mg, belladonna 8mg.
[usage and dosage] oral. A 2 piece. The first day of service 3 times, 2 times a day after.1 to 5 for a course of treatment, continue to take the need to follow the doctor's advice.
[adverse reactions]
1 allergic reactions are most common, can be expressed as drug rash, severe cases can exudative erythema multiforme, peel off dermatitis and bullous epidermal lysis atrophy dermatitis; also has the performance as a photosensitive reaction, drug fever, joint and muscle pain, fever and other serum sickness like response. I see anaphylactic shock.
Neutrophils reduced or deficiency, thrombocytopenia syndrome and aplastic anemia. Patients may show a sore throat, fever, pale and bleeding tendency.
3 hemolytic anemia and hemoglobin in urine. The lack of glucose - 6 - phosphate dehydrogenase with sulfa drugs is easy to occur, in neonates and children than adults to see more.
4 hyperbilirubinemia and neonatal nuclear jaundice. Due to the goods and bilirubin competitive protein binding site, increased can cause of unconjugated bilirubin, neonatal liver function is not perfect, the bilirubin poor handling of the, so it is easy to hyperbilirubinemia, neonatal jaundice, and even can cause kernicterus.
5 liver damage can occur in jaundice, liver function decline, severe cases of acute liver necrosis can occur.
6 renal damage may occur crystallization urine, hematuria, urinary tube; the serious adverse reactions between patients with occasional occurrence of matter nephritis and renal tubular necrosis.
7 nausea, vomiting, appetite loss, diarrhea, headache, fatigue and other mild symptoms generally. C. difficile bacteria enteritis in occasional patients, this time to discontinuation of the drug.
8 thyroid enlargement and dysfunction occur occasionally.
9 central nervous system toxicity may occur occasionally, as a result of mental disorders, directional force disorders, hallucinations, pleasure or a sense of depression.
10 dry mouth, blurred vision, heart rate, skin flushing, dizziness etc. can have serious mydriasis, excitement, irritability.
1 allergy to SMZ and TMP is disabled.
2 is disabled by the giant young red blood cell anemia patient.
3 pregnant women and lactating women disabled.
4 infants and 2 months of infants are disabled.
5 severe liver and kidney dysfunction disabled.
6 glaucoma, high intraocular pressure patients are disabled.
7 patients with tachycardia were disabled.
8 hypertrophy of the prostate patients disabled.
9 patients with obstruction of H. pylori were disabled.
[note] [note]
1 cross allergic reaction to a patient who is allergic to a drug allergy to other drugs may also be allergic to drugs.
2 liver damage can occur in jaundice, liver function decline, severe cases of acute liver necrosis can occur, so there is a liver function damage patients should avoid the application.
3 kidney damage may occur crystallization urine, hematuria, urinary tube, so taking this product should water more, maintain high urine flow, such as the application of the long course of treatment, in large doses, in addition to the water outside, should with sodium bicarbonate, to prevent the adverse reaction, dehydration, shock and elderly patients with application of this product is prone to cause kidney damage, should be used with caution or avoid using this product. Patients with renal impairment should not use this product.
4 of furosemide, S-dioxide, thiazide diuretics, sulfonylurea, carbonic anhydrase inhibitors present in allergic patients allergic to sulfa drugs also.
5 patients with gastric and duodenal ulcer and heart failure with caution.
[pregnant women and breastfeeding women medication]
This product can pass through the blood placenta barrier to the fetus, animal experiments found that the teratogenic effect. This product can be self breast milk secretion, breast milk concentration up to about maternal serum concentration of 50% ~ 100%, the drugs may affect the baby. This product in glucose - 6 - phosphate dehydrogenase deficiency neonates in application has lead to the occurrence of hemolytic anemia. So breast-feeding women should not be used this product.
[children's drug use]
Because of this product can compete with bilirubin in plasma protein binding site, and neonatal acetyl transfer enzyme system development not perfect, Sulfanilamide and free blood concentration increased, resulting in increased risk of kernicterus, so this kind of drugs in neonates and 2 months following the baby should be banned. Children are in the growth and development period, liver and kidney function is not perfect, dosage should be discounted.
[old age medication]
Elderly patients were treated with this product occurs when serious adverse reaction of the opportunity to increase: such as severe skin rash and other allergic reactions and bone marrow suppression, reduction in white blood cells and platelet reduced blood system abnormalities, and application of diuretics are more likely to occur. Therefore in elderly patients should avoid the use of, and indeed there is a sign need to weigh the pros and cons decided.
[drug overdose]
The blood concentration of the product should not exceed 200 g/ml, more than this concentration, the incidence of adverse reaction increased and enhanced toxicity. Excessive short-term use of this product will appear anorexia, abdominal pain, nausea, vomiting, dizziness, headache, drowsiness, confusion, low spirit, fever, hematuria, urinary crystals, blood disease, jaundice, bone marrow the general treatment for depression. After discontinuation of gastric lavage, vomiting or drinking a lot of water; can give infusion therapy, urine volume low and normal renal function. In the course of treatment should be monitored for blood, such as electrolyte. There was obvious hematological adverse reactions or jaundice, should be treated as myelosuppression of hemodialysis. First, stop, given folic acid 3 ~ 6mg intramuscular injection, 1 times a day for 3 days or until the hematopoietic function returned to normal so far. This product may cause long-term overdose caused by bone marrow suppression, platelet, leukopenia and megaloblastic anemia of bone. Bone marrow suppression symptoms, patients should be daily intramuscular injection of leucovorin 5 ~ 15mg therapy, hematopoietic function returned to normal.
[pharmacological and toxicological]
This product is a compound, is a broad-spectrum antibiotic sulfonamides. Sulfamethoxazole (SMZ) and trimethoprim (TMP) have synergistic antibacterial effect. The non enzyme production of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, proteus. Morgan spp., Shigella and other Enterobacteriaceae bacteria, Neisseria gonorrhoeae, Neisseria meningitis, Haemophilus influenzae has good antibacterial effect, especially for Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, the antibacterial effect of SMZ was significantly higher than the single drug. In addition to in vitro enhancement of Chlamydia trachomatis, Nocardia asteroids. Protozoan, Toxoplasma gondii also has good anti microbial activity. The mechanism is that the role of SMZ in the first step of dihydrofolate synthase, interfere with folic acid synthesis, TMP second step in folate synthesis metabolism, inhibition of dihydrofolate reductase for selection With the combination of the two can make the folic acid metabolism of bacteria by double blocking. The product of the synergistic antibacterial effect than single drug enhancement, reduce the presentation of drug-resistant strains. However in recent years the bacterial resistance to this product also increased. M belladonna muscarinic receptor blocking drugs, can inhibit muscarinic acetylcholine. Mainly, inhibition of postganglionic cholinergic innervation of the acetylcholine independent effector site activities by acetylcholine innervation of the smooth muscle activity was also inhibited. Inhibition of smooth muscle, myocardium, sinoatrial node and atrioventricular node, and the exocrine glands excited. A large amount of belladonna can reduce gastrointestinal motility and secretion, lower ureter the bladder and the tension of the common bile duct and gallbladder only slightly loose.
Light shade, sealed, in the dry place to save.
[packing] (1) plastic bottles: 10 / bottle, 100 tablets / bottle; (2) packing: 12 / 1 plate, plate / box.
[Effective] 24 months
[executive standard] WS-10001- (HD-1005) -2002
[approval] Zhunzi H32025897